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hasR hasR hasAp hasAp hasD hasD hemO hemO PA3409 PA3409 pfeA pfeA tonB1 tonB1 exbD1 exbD1 hmuV hmuV pvdS pvdS PA3900 PA3900
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hasRHeme uptake outer membrane receptor HasR precursor; Product name confidence: Class 2 (High similarity to functionally studied protein). (891 aa)    
Predicted Functional Partners:
hasAp
Heme acquisition protein HasAp; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
  
 
 0.977
hasD
Transport protein HasD; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
  
 0.961
hemO
Heme oxygenase; Involved in heme degradation. Catalyzes the degradation of heme to biliverdin, with the release of iron. Forms biliverdin delta (70%) and beta (30%).
 
  
 0.960
PA3409
Probable transmembrane sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
  
 0.902
pfeA
Ferric enterobactin receptor, outer membrane protein PfeA precursor; Specific receptor for the siderophore ferric enterobactin.
  
  
 0.828
tonB1
TonB1; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
 
 
 0.816
exbD1
Transport protein ExbD; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
  
  
 0.796
hmuV
Probable ATP-binding component of ABC transporter; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.
 
  
 0.703
pvdS
Sigma factor PvdS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the sigma-70 factor family. ECF subfamily.
 
  
 0.700
PA3900
Probable transmembrane sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
  
 0.686
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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